Tuberculous meningitis in infants and children: Insights from nuclear magnetic resonance metabolomics
نویسندگان
چکیده
AFFILIATIONS: 1Centre for Human Metabonomics, Faculty of Natural Sciences, North-West University, Potchefstroom Campus, Potchefstroom, South Africa 2Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Stellenbosch, South Africa 3Department of Paediatric Infectious Diseases and Immunology, VU University Medical Center, Amsterdam, the Netherlands
منابع مشابه
Cerebrospinal fluid in tuberculous meningitis exhibits only the L-enantiomer of lactic acid
BACKGROUND The defining feature of the cerebrospinal fluid (CSF) collected from infants and children with tuberculous meningitis (TBM), derived from an earlier untargeted nuclear magnetic resonance (NMR) metabolomics study, was highly elevated lactic acid. Undetermined was the contribution from host response (L-lactic acid) or of microbial origin (D-lactic acid), which was set out to be determi...
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